The Blob suddenly appears after crashlanding in a rural area outside of the fictional ski resort town of Arborville, CA. It attaches itself to the hand of a vagrant, Star high school wide receiver Paul Taylor (Donovan Leitch) and his cheerleader crush Meg Penny (Shawnee Smith) are out on their first date when they come across the man, taking him to the hospital, along with the town’s juvenile delinquent, Brian Flagg (Kevin Dillon), who they think is responsible. They soon discover that the blob has eaten the man alive, and is growing larger. As it heads to town to feed the Blob is revealed to be a runaway bio-weapon experiment invented by the US military. Secret government operatives quarantine the town. They want the Blob back alive; the town’s residents are expendable. It’s up to the teens to save the day. Chuck Russell directs from a script written by Russell and Frank Darabont.
John Candy plays Harry Crumb, the bumbling son who never quite lived up to the reputation of his sleuthing father and grandfather in his family’s long-standing detective agency. Instead of running the company, he’s been relegated to being a lowly trainee as their Tulsa office. Ineptitude is just what the CEO of the company, Eliot Draisen (Jeffrey Jones), in Los Angeles wants from an investigator for reasons of his own. Draisen flies out Crumb to Los Angeles to crack the case involving the kidnapping and ransom of Jennifer Downing, the beautiful heiress daughter of P.D. Downing (Barry Corbin) and his philandering new wife Helen (Annie Potts). Crumb begins to use his penchant for disguises to get to the bottom of things.